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目的采用D试验检测(1,3)-β-D葡聚糖含量,探讨对早产儿侵袭性真菌感染的诊断价值。方法选择2012年1月至2014年12月在南方医科大学附属小榄医院NICU住院的早产儿以D试验检测(1,3)-β-D葡聚糖,同时进行血真菌培养,分析其含量水平及阳性率,并评价其诊断价值。结果 260例同时作血培养和(1,3)-β-D葡聚糖检测,送检率10.29%(260/2 525)。(1,3)-β-D葡聚糖阳性率12.31%(32/260),显著高于血培养阳性率的3.84%(10/260),差异有统计学意义(P<0.05);早产儿发现感染时(1,3)-β-D葡聚糖水平(258.0±210.0)pg/m L显著高于治疗1周后水平(37.5±17.15)pg/m L,差异有统计学意义(P<0.01)。结论检测血(1,3)-β-D葡聚糖,可作为有真菌感染危险因素早产儿的筛查项目,对早产儿侵袭性真菌感染具有早期诊断价值。
Objective To detect the content of (1,3) -β-D-glucan by D test, and to explore the diagnostic value of invasive fungal infection in premature infants. METHODS: From January 2012 to December 2014, preterm infants admitted to NICU in Siu Lam Hospital, Southern Medical University were tested for D-test (1,3) -β-D-glucan, and blood fungus culture was carried out to analyze its content Level and positive rate, and evaluate its diagnostic value. Results 260 cases of blood culture at the same time and (1,3) -β-D-glucan test, the rate was 10.29% (260/2 525). The positive rate of (1, 3) -β-D-glucan was 12.31% (32/260), which was significantly higher than 3.84% (10/260) of the positive rate of blood culture, the difference was statistically significant (P <0.05) The level of (1,3) -β-D-glucan (258.0 ± 210.0) pg / m L was significantly higher than that after 1 week (37.5 ± 17.15) pg / m L, and the difference was statistically significant P <0.01). Conclusion The detection of blood (1,3) -β-D-glucan can be used as a screening item for preterm infants with risk of fungal infection and has early diagnostic value for invasive fungal infection in premature infants.