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目的了解杭州市区铜绿假单胞菌对亚胺培南与美罗培南不同耐药模式菌株对临床常用其他抗菌药物的耐药情况。方法选取2006年8月至2007年1月杭州市4家医院分离的铜绿假单胞菌378株,对不同城区分离的铜绿假单胞菌进行药物敏感性检测,对亚胺培南与美罗培南不同的耐模式菌株进行分类统计,同时观察其对其他抗菌药物的耐药率。结果在378株细菌中观察到亚胺培南与美罗培南的8种耐药模式,分别为S/S,66.1%(250/378);R/R,20.6%(78/378);S/R,5.0%(19/378);R/S,3.4%(13/378);I/R,1.9%(7/378);R/I,1.3%(5/378);I/S,1.1%(4/378);S/I,0.5%(2/378)(S为敏感,I为中介,R为耐药)。对其他8种抗菌药物的敏感性检测结果显示,S/S与S/I及I/S模式耐药性最低,均低于10%,R/R最高,均高于44%。R/S与S/R模式对不同的抗菌药物耐药率有较大不同。结论杭州市区流行的菌株以S/S,R/R,S/R,R/S 4种模式为主,占所有模式中的95%以上,其中又以S/S模式最为多见,不同模式菌株对其他抗菌药物的耐药性有较大差异,临床可通过不同的耐药模式进行耐药机制推断,合理选用抗菌药物治疗。
Objective To understand the resistance of Pseudomonas aeruginosa in Hangzhou city to different antibacterials commonly used in clinical practice in different drug resistant strains of imipenem and meropenem. Methods 378 strains of Pseudomonas aeruginosa isolated from 4 hospitals in Hangzhou City from August 2006 to January 2007 were selected to test the drug susceptibility of Pseudomonas aeruginosa isolated in different urban areas. The sensitivity of imipenem to meropenem Different resistant strains were classified statistics, and observed its resistance to other antibiotics. Results The resistance patterns of imipenem and meropenem were observed in 378 strains of bacteria, which were S / S, 66.1% (250/378), R / R, 20.6% (78/378) R / I, 1.3% (5/378); I / R, 1.9% (7/378); R / 1.1% (4/378); S / I, 0.5% (2/378) (S is sensitive, I is mediator, R is resistant). The sensitivity of the other 8 antimicrobial agents showed that the S / S and S / I and I / S models had the lowest drug resistance, both lower than 10% and the highest R / R, both higher than 44%. R / S and S / R patterns of different antimicrobial resistance rates are quite different. Conclusion Four strains of S / S, R / R, S / R and R / S are the dominant strains in Hangzhou, accounting for more than 95% of all the patterns, of which S / S pattern is the most common and different Modes of strains of other antibacterial drug resistance are quite different clinical resistance through different drug resistance mechanisms inferred, rational use of antimicrobial agents.