论文部分内容阅读
AIM:To evaluate the validity of ultrasonographic andpathologic diagnosis of liver fibrosis in patients withchronic viral hepatitis.METHODS:The liver fibrosis status in 324 patients wasevaluated by both needle biopsy and ultrasonography.Liver fibrosis was divided into S0-S4 stages.S4 stagewas designated as definite cirrhosis.The ultrasonograph-ic examination included qualitative variables,descriptionof liver surface and parenchyma,and quantitative pa-rameters,such as diameter of vessels,blood flow veloc-ity and spleen size.RESULTS:Ultrasonographic qualitative description of liv-er surface and parenchyma was related with the severityof fibrosis.Among the quantitative ultrasonographic pa-rameters,cut-off value of spleen length(12.1 cm)had asensitivity of 0.600 and a specificity of 0.753 for diagno-sis of liver cirrhosis.The diameters of spleen(8 mm)andportal vein(12 mm)had a diagnostic sensitivity of 0.600and 0.767,and a diagnostic specificity of 0.781 and 0.446,respectively.The diagnostic accuracy for liver cirrhosiswas moderately satisfactory,and the negative predictivevalues of these parameters reached near 0.95.CONCLUSION:Ultrasonography can predict the degreeof liver fibrosis or cirrhosis.A single ultrasonographicparameter is limited in sensitivity and specificity for thediagnosis of early cirrhosis.The presence or absence ofliver cirrhosis in patients with chronic virus hepatitis canbe detected using 2 or 3 quantitative and qualitative pa-rameters,especially the length of spleen,the diameterof spleen vein and echo pattern of liver surface.
AIM: To evaluate the validity of ultrasonographic and pathologic diagnosis of liver fibrosis in patients with chronic viral hepatitis. METHODS: The liver fibrosis status in 324 patients wasevaluated by both needle biopsy and ultrasonography. Liver fibrosis was divided into S0-S4 stages. Stage 4 waswas designated as definite cirrhosis.The ultrasonograph-ic examination included qualitative variables, descriptionof liver surface and parenchyma, and quantitative pa-rameters, such as diameter of vessels, blood flow veloc-ity and spleen size .RESULTS: Ultrasonographic qualitative description of liv-er surface and A study of the severity of fibrosis. Among the quantitative ultrasonographic pa-rameters, cut-off value of spleen length (12.1 cm) had a sensitivity of 0.600 and a specificity of 0.753 for diagno-sis of liver cirrhosis. These diameters of spleen (8 mm) and portal vein (12 mm) had a diagnostic sensitivity of 0.600 and 0.767, and a diagnostic specificity of 0.781 and 0.446, respectively. The diagnosti c accuracy for liver cirrhosis was moderately satisfactory, and the negative predictive values of these parameters reached near 0.95. CONCLUSION: Ultrasonography can predict the degree of liver fibrosis or cirrhosis. A single ultrasonographic parameter is limited in sensitivity and specificity for the diagnosis of early cirrhosis. the presence or absence ofliver cirrhosis in patients with chronic virus hepatitis canbe detected using 2 or 3 quantitative and qualitative pa-rameters, especially the length of spleen, the diameter of spleen vein and echo pattern of liver surface.