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目的:分析肥胖儿童胰岛素释放实验的结果及临床意义。方法:选取我院51例单纯性肥胖患儿及同期体检者45例,均采用全自动化学发光免疫分析仪DXI800进行检测,检测两组患者空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、血糖曲线下面积(AUCG)、胰岛素曲线下面积(AUCI)以及AUCG/AUCI、FBG/FINS比值,并分析两组胰岛素释放试验结果差异。结果:肥胖组FBG、HOMA-IS与正常组比较无统计学意义(P>0.05),而肥胖组FINS、HOMA-IR为(14.39±5.82)mIU/L、(0.91±0.42)显著高于正常组(7.25±2.62)mIU/L、(0.21±0.18),对比差异显著(P<0.05),肥胖组HOMA-IAI、AUCG/AUCI、FBG/FINS分别为(-4.15±0.77)、(0.17±0.05)、(0.41±0.17)与正常组(-3.41±0.40)、(0.56±0.27)、(0.89±0.34)比较显著较低(P<0.05);肥胖组空腹胰岛素、1h、2h、3h胰岛素均显著高于正常组(P<0.05),两组3h时胰岛素水平逐渐恢复,与空腹水平比较无统计学意义(P>0.05)。结论:胰岛素释放试验是检测肥胖儿童胰岛素抵抗等指标的有效方式,肥胖儿童常见胰岛素抵抗,需引起临床重视,从而及时采取干预措施以降低肥胖儿童发生糖尿病的风险。
Objective: To analyze the results and clinical significance of insulin release test in obese children. Methods: Fifty-one children with simple obesity in our hospital and 45 normal subjects were enrolled in this study. All patients were tested by DXI800 automated chemiluminescence immunoassay analyzer. The levels of fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance HOMA-IR, AUCG, AUCI, AUCG / AUCI and FBG / FINS were calculated and the differences of insulin release test between the two groups were analyzed. Results: The FBG and HOMA-IS levels in obesity group were not significantly different from those in normal group (P> 0.05), while those in obesity group were (14.39 ± 5.82) mIU / L and (0.91 ± 0.42) The levels of HOMA-IAI, AUCG / AUCI and FBG / FINS were (-4.15 ± 0.77) and (0.17 ± 0.77) in the obesity group (7.25 ± 2.62 mIU / L and 0.21 ± 0.18 respectively) 0.05). The level of fasting insulin, 1h, 2h, 3h insulin in obese group was significantly lower than that in normal group (-3.41 ± 0.40), (0.56 ± 0.27) and (0.89 ± 0.34) (P <0.05). The levels of insulin in the two groups recovered gradually at 3h, which were not significantly different from the fasting levels (P> 0.05). Conclusion: The insulin release test is an effective way to detect insulin resistance in obese children. Common obesity in children with insulin resistance needs to pay more attention to the clinical practice, so interventions can be taken in time to reduce the risk of developing diabetes in obese children.