【摘 要】
：
Axon regeneration requires protein synthesis and membrane expansion. The presence of granular material was discovered in the perikaryon of neurons but not axons using Nissl staining (Gomes, 2019). This is one of the characteristic features of neurons and
【机 构】
：
Graduate Program in Molecular and CellularPharmacology,Miami Integrative Metabolomics Research Cente
论文部分内容阅读
Axon regeneration requires protein synthesis and membrane expansion. The presence of granular material was discovered in the perikaryon of neurons but not axons using Nissl staining (Gomes, 2019). This is one of the characteristic features of neurons and we now know that RNA content of the granular material stains with Nissl stain. Although no Nissl granules are present in axons, mRNA can be shuttled to distal axons for local protein synthesis. Axonal protein synthesis only makes up a small portion as the majority occurs in the perikaryon. The required membrane expansion and protein synthesis machinery are still present in the adult central nervous system (CNS) axon.
其他文献
The knockout of the chemokine C-X-C motif chemokine receptor 4 (CXCR4) in growth-stimulated retinal ganglion cells (RGCs) has a multiplicative effect on optic nerve regeneration. C-X-C motif chemokine ligand 12 (CXCL12), the exclusive ligand of CXCR4, is
The term immunophilin involves a family of proteins whose domain shows peptidyl-prolyl-(cis/trans)-isomerase (PPIase) enzymatic activity, i.e., the reversible cis/trans interconversion of Xaa-Pro bonds (Annett et al., 2020). The PPIase domain of these pro
Neurons of the mature central nervous system (CNS, mainly the brain and spinal cord) are unable to regenerate spontaneously after a lesion, in contrast to neurons of the peripheral nervous system (PNS). While the extraneuronal environment was long thought
The neuromodulatory transmitter serotonin(5-hydroxytryptamine,5-HT)is synthesized by neurons located in the brainstem,which project more or less densely to the entire central nervous system(Charnay and Leger,2010).
Parkinson\'s disease (PD) is one of the most common neurodegenerative diseases, affecting individuals especially over 60 years of age. In the next three decades, more than 12 million people will suffer from PD worldwide (Rocca, 2018). The characteristic
A chronic phase following repetitive mild traumatic brain injury can present as chronic traumatic encephalopathy in some cases, which requires a neuropathological examination to make a definitive diagnosis. Positron emission tomography (PET) is a molecula
Neurons undergo activity-dependent changes in their molecular composition and structure in order to regulate cellular processes such as dendritic growth, synapse elimination, spine maturation and synaptic strength. Such synaptic plasticity plays an import
Exercise and brain health: Physical activity helps promote and maintain our brain health, including memory and cognitive performance. Research has shown that exercise is a safe behavioral intervention that reduces the risk of hypokinetic diseases, such as
Among the risk factors for late onset sporadic Alzheimer\'s disease (AD) is the expression of ε4 allele of apolipoprotein E (APOE4) gene (Mahley et al., 2006). Elevated amyloid processing and reduced degradation of Aβ, which lead to Aβ plaque deposition
The devastating outbreak of the ongoing coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has affected not only the lives of almost everyone around the world but also the governments and societies as we