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目的:探讨PTEN和P16蛋白在鼻内翻性乳头状瘤(NIP)中的表达及与肿瘤发生、发展、预后的关系。方法:采用免疫组织化学SP法和计算机图像分析系统,检测27例NIP和10例正常蝶窦黏膜中PTEN、P16蛋白的表达,并对两者在不同NIP预后分组中的表达进行对比分析。结果:PTEN和P16蛋白在NIP组织中的表达与正常蝶窦黏膜相比,均差异有统计学意义(均P<0.05)。NIP无复发组PTEN蛋白的表达下降,与复发组比较差异有统计学意义(P<0.05);P16蛋白的表达下调在不同预后效果的NIP分组间差异无统计学意义(P>0.05)。结论:PTEN蛋白减少或缺失是NIP发生、发展及不良预后的重要指标,P16蛋白亦与NIP的发生、发展相关,两者具有重要的临床意义。
Objective: To investigate the expression of PTEN and P16 protein in nasal inverted papilloma (NIP) and its relationship with tumorigenesis, development and prognosis. Methods: Immunohistochemical SP method and computer image analysis system were used to detect the expression of PTEN and P16 in 27 cases of NIP and 10 cases of normal sphenoid sinus mucosa, and their expressions in different NIP prognostic groups were compared. Results: The expressions of PTEN and P16 protein in NIP tissue were significantly different from those in normal sphenoid mucosa (all P <0.05). The expression of PTEN protein in non-recurrence group was significantly lower than that in recurrence group (P <0.05). There was no significant difference in the expression of P16 between NIP group and non-recurrence group (P> 0.05). Conclusion: The decrease or loss of PTEN protein is an important index of occurrence, development and adverse prognosis of NIP. P16 protein is also associated with the occurrence and development of NIP, both of which have important clinical significance.