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目的应用啮齿类动物、细胞、线虫3种实验模型同步进行毒性研究,摸索危险废液毒性初筛方法及判定标准的新模式。方法对18件工业废水进行毒性评估,以急性毒性评价为基点,同步进行动物急性经口毒性、经皮毒性、经呼吸道毒性试验;线虫毒性试验(24h LC50);细胞毒性试验(24h LC50)。结果 18件样品小鼠急性经口LD50>5000 mg/kg,小鼠急性吸入LC50>10 mg/L,大鼠急性经皮LD50>2000 mg/kg;18件样品的线虫半数致死浓度(24hLC50)为253.1~869.6 mg/ml;18件样品的中性红细胞毒性半数致死浓度(24h LC50)为19.87~75.93 mg/ml,结论动物试验结果表明18件样品不属于危险废液;4件样品215 mg/ml、14件样品464 mg/ml提示对线虫有毒性作用;本研究为建立危险废液快速、廉价、实用的多模式毒性评估体系提供了初步的科学依据;为应对公共卫生事件中不明危险废液的快速预筛检和判别提供了有潜在价值的评估技术。
OBJECTIVE: To study the toxicity of rodents, cells and nematodes using three experimental models simultaneously, and to explore the new method of screening methods and criteria of toxicity of hazardous waste liquid. Methods The toxicity of 18 industrial wastewaters was evaluated. Acute toxicity was evaluated as the starting point. Acute oral toxicity, transdermal toxicity and respiratory toxicity test were simultaneously performed. The nematode toxicity test (24h LC50) and cytotoxicity test (24h LC50) were performed simultaneously. Results The acute oral LD50> 5000 mg / kg, acute inhaled LC50> 10 mg / L and acute dermal LD50> 2000 mg / kg were obtained from 18 samples of mice. The median lethal concentration (24hLC50) Of the 18 samples were 19.87-75.93 mg / ml. The results of the animal experiment showed that 18 samples were not hazardous waste liquid and the other four samples were 215 mg / ml and 14 samples at 464 mg / ml, suggesting that it is toxic to nematodes. This study provides a preliminary scientific basis for establishing a rapid, inexpensive and practical multimodal toxicity assessment system for hazardous waste liquid. In response to unknown risks in public health events Rapid pre-screening and determination of waste fluids offers potentially valuable assessment techniques.