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目的探讨C反应蛋白(CRP)与川崎病患儿并发冠状动脉病变的关系。方法全面检索各中文数据库,收集2000年1月至2009年12月国内公开发表的和学位论文中关于川崎病并发冠状动脉病变与CRP有关的临床资料,采用Cochrane协作网提供的Review Manger软件(Revm an4.2),对所纳入的研究数据的计数资料进行Meta分析,根据文献异质性检验结果,选择固定效应模型,计算比值比及其95%的可信区间,并行敏感性分析及偏倚性分析。计量资料计算加权均数差(WMD)及其95%的可信区间。结果共有19项研究符合纳入标准,计数资料统计结果示,CRP>100m g/L[OR=2.37,95%C I=(1.49,3.77),P=0.000 3];计量资料统计结果示,WMD=19.02,95%C I=(11.98,26.05),P<0.000 01。结论 CRP与中国川崎病患儿发生冠脉病变密切相关,CRP>100m g/L为其高危因素之一。
Objective To investigate the relationship between C-reactive protein (CRP) and coronary artery lesions in children with Kawasaki disease. Methods The Chinese databases were retrieved from January 2000 to December 2009. The clinical data of Kawasaki disease complicated with coronary artery disease and CRP in domestic published and dissertations were collected. The review Manger software provided by the Cochrane Collaboration (Revm an4.2). Meta-analysis was performed on the count data of the included research data. Based on the document heterogeneity test results, a fixed effect model was selected to calculate the odds ratio and its 95% confidence interval. Parallel sensitivity analysis and bias analysis. The metrological data were used to calculate the weighted mean difference (WMD) and its 95% confidence interval. Results A total of 19 studies met the inclusion criteria. The statistics of counting data showed that CRP> 100 m g / L [OR = 2.37, 95% CI = (1.49, 3.77), P = 0.0003] 19.02, 95% CI = (11.98, 26.05), P <0.000 01. Conclusion CRP is closely related to coronary artery disease in children with Kawasaki disease in China. CRP> 100m g / L is one of the risk factors.