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用阿斯匹林(ASA)治疗缺血性脑血管病疗效肯定。但以前应用的剂量较大,现在较一致认为小剂量既能取得满意的效果。而用小剂量ASA治疗老年人(60岁以上)的缺血性脑血管病尚未见报道。本文报道30例,肠溶ASA0.3克隔日1次18例;普通ASA0.1g每日1次12例,治疗效果满意。且未发现副反应。26例(患者12例,正常人14名)进行了血药浓度监测。结果服药后2—4小时血药浓度达高峰,24小时基本排完。16例(10例患者,6名正常人)动态观察了血小板聚集力的变化。结果示ASA对血小板聚集力有明显抑制作用,且一次用药作用持续时间较久,服药后7天才基本恢复至服药前水平,提示用药时间间隔可更长或剂量可更小。通过对血小板聚集力的监测,ASA的疗效从理论上亦得到了证实。
Aspirin (ASA) for the treatment of ischemic cerebrovascular disease is certainly effective. However, the larger dose used in the past, now more consistent that small doses can achieve satisfactory results. However, the treatment of ischemic cerebrovascular disease with low-dose ASA in the elderly (over 60 years of age) has not been reported. This article reports 30 cases, enteric ASA0.3 grams every other day in 18 cases; ordinary ASA0.1g once a day in 12 cases, the treatment effect is satisfactory. No side effects were found. Twenty-six patients (12 patients and 14 normal subjects) underwent blood concentration monitoring. Results 2-4 hours after taking the drug peak plasma concentration, 24 hours basically finished row. Sixteen patients (10 patients and 6 normal subjects) dynamically observed the change of platelet aggregation. The results showed that ASA had a significant inhibitory effect on platelet aggregation, and a long duration of medication, medication was recovered to the level of 7 days before taking, suggesting that the medication interval may be longer or the dose may be smaller. Through the monitoring of platelet aggregation, the efficacy of ASA has also been confirmed.