目的　探讨慢性支气管炎 (下称慢支 )患者所伴随的细胞免疫功能变化 ,特别是 CD95的百分率变化。方法　流式细胞术检测 40例慢支患者和 2 0例健康老人外周血 T淋巴细胞亚群及 CD95的百分率。结果　慢支组与健康组比较 ,CD3、 CD4明显降低 ,CD8升高 ,同时发现慢支组的 CD3+、CD4+细胞 CD95含量较健康组明显升高 ,CD8+细胞 CD95含量较健康组略有升高。结论　 CD4+细胞通过表达 CD95杀伤自己 ,在免疫反应的调节中表现为主动凋亡 ,慢支组 CD8+细胞百分率明显增高是慢支组患者外周血淋巴细胞 CD95高表达的原因 Objective To investigate the changes of cellular immune function in patients with chronic bronchitis (chronic bronchitis), especially the percentage change of CD95. Methods The percentage of T lymphocyte subsets and CD95 in 40 patients with chronic bronchitis and 20 healthy controls were detected by flow cytometry. Results Compared with the healthy group, the levels of CD3 and CD4 in the chronic bronchitis group and the CD8 in the chronic bronchitis group were significantly higher than those in the healthy group. The levels of CD95 in the CD3 + and CD4 + cells in the chronic bronchitis group were significantly higher than those in the healthy group. Conclusions CD4 + cells kill CD40 by expressing CD95 and show active apoptosis in the regulation of immune response. The percentage of CD8 + cells in chronic bronchitis group is significantly higher than that in chronic bronchitis group