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目的探讨外用重组牛碱性成纤维细胞生长因子(bFGF,见林)喷雾剂治疗颌面部软组织擦伤的临床疗效。方法对2007年至2010年共收治136例颌面部软组织擦伤的患者,按随机抽取的方法将患者分为bFGF喷雾剂治疗组及外科常规治疗组,观察擦伤创面的愈合方式、局部治疗反应、药物止痛效果及不良反应。结果两组患者均治愈,bF-GF喷雾剂治疗组无明显瘢痕增生,平均愈合期10 d;外科常规治疗组有21例产生瘢痕增生,平均愈合期13 d。在半年时复查,bFGF喷雾剂治疗组创口愈合后创面区域瘢痕平整无增生,皮肤无色素沉积;外科常规治疗组创面区域瘢痕增生,皮肤有色素沉积。结论 bFGF喷雾剂治疗颌面部软组织擦伤优于外科常规治疗法,是一种疗效显著的治疗皮肤软组织擦伤的首选外用药。
Objective To investigate the clinical effect of topical bFGF injection on the maxillofacial soft tissue abrasion. Methods A total of 136 patients with maxillofacial soft tissue injuries from 2007 to 2010 were randomly divided into bFGF spray treatment group and conventional surgical treatment group to observe the wound healing method and local treatment Reaction, analgesic effect and adverse reaction. Results The two groups of patients were cured. There was no significant scar hyperplasia in the bF-GF spray group, with an average healing time of 10 days. There were 21 cases with scar hyperplasia in the conventional surgical group, with an average healing time of 13 days. After six months of review, bFGF spray treatment group wound healing wound surface without hyperplasia, no skin pigmentation; surgical routine treatment group wound area scar hyperplasia, skin pigmentation. Conclusion bFGF spray treatment of maxillofacial soft tissue injury is superior to conventional surgical treatment, is a curative effect of the treatment of skin and soft tissue abrasions of choice for topical drugs.