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目的:观察T细胞分化蛋白2(Mal2)在肝细胞癌(HCC)中的表达并探讨其临床意义。方法:采用免疫组织化学染色方法检测226例HCC患者的肿瘤组织和86例正常肝组织中Mal2蛋白的表达情况,并分析其与HCC临床病理指标的关系。通过生存分析比较不同Mal2表达水平患者的生存情况,并分析影响HCC患者生存情况的危险因素。结果:Mal2蛋白在HCC肿瘤组织中的表达水平显著高于正常肝组织(P<0.05)。Mal2蛋白表达水平增高与HCC患者血管侵犯、淋巴结转移和较高的TNM分期相关。生存分析表明Mal2蛋白高表达组患者术后生存率显著低于低表达组患者(P<0.05)。Mal2阳性表达、血管癌栓形成、淋巴结转移及较高的TNM分期是影响HCC患者术后生存时间的独立危险因素。结论:Mal2蛋白在HCC组织中呈过表达趋势,且与肿瘤转移密切相关,可能在HCC的诊断与预后判断中有一定的应用价值。
Objective: To observe the expression of Mal2 and its clinical significance in hepatocellular carcinoma (HCC). Methods: Immunohistochemical staining was used to detect the expression of Mal2 protein in 226 HCC patients and 86 normal liver tissues. The relationship between the Mal2 protein expression and clinicopathological parameters of HCC was analyzed. The survival of patients with different Mal2 expression levels was compared by survival analysis and the risk factors influencing the survival of HCC patients were analyzed. Results: The expression level of Mal2 protein in HCC tissues was significantly higher than that in normal liver tissues (P <0.05). Mal2 protein expression increased with vascular invasion of HCC patients, lymph node metastasis and higher TNM stage. Survival analysis showed that the survival rate of patients with high expression of Mal2 protein was significantly lower than that of patients with low expression (P <0.05). Mal2 positive expression, vascular thrombosis, lymph node metastasis and high TNM staging are independent risk factors influencing the postoperative survival time of patients with HCC. Conclusion: Mal2 protein is overexpressed in HCC tissue and is closely related to tumor metastasis. It may have some value in the diagnosis and prognosis of HCC.