多发性骨髓瘤是以骨髓中浆细胞恶性增生为特征的一种自身免疫病。本病并非罕见,国外发病率为2～3/10万人口,国内近来有逐渐增多趋势,发病年龄以50～70岁居多,男性约2倍于女性。本文报告2例,均经骨髓检查证实。 例1 女性48岁,因周身疼痛一年半,左上肢活动受限6个月,于1980年2月9日入院。 病人于1978年6月开始,无明显诱因,自感全身关节及骨骼疼痛伴鼻出血,服一般止痛药无效乃去医院检查,经做骨穿,及拍全身骨骼照片,诊断为“多发性骨髓瘤”病人先在我院门诊治疗2个月,口服环磷酰胺片,静注长春新硷及自服消瘤芥(AT—1258)致病情一度好转,能参加一般家务劳动,唯头部脱 Multiple myeloma is an autoimmune disease characterized by malignant hyperplasia of plasma cells in the bone marrow. The disease is not uncommon, the foreign incidence of 2 to 3/10 million population, the recent gradual increase in the domestic trend, the age of onset to 50 to 70-year-old mostly men about 2 times the women. This article reports 2 cases, confirmed by bone marrow examination. Example 1 A 48-year-old female was admitted to hospital on February 9, 1980, for a year and a half with full-blown pain and a 6-month limited upper left limb activity. The patient started in June 1978 with no obvious incentive to feel joint and bone pain with nosebleeds. The general painkiller medication was ineffective and went to the hospital for examination. After bone formation and whole-body photo biopsy, the patient was diagnosed as “multiple bone marrow Tumor ”patients in our hospital outpatient treatment for 2 months, oral cyclophosphamide tablets, intravenous injection of vincristine and spontaneous tuber mustard (AT-1258) pathogenic condition was improved, to participate in general housework, the only head Off