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自从70年代初正式命名突触前受体以来,其发展异常迅速.本文综述突触前肾上腺素受体(侧重α-受体)的分类、功能、作用机理、生理意义和药理意义等方面的一些进展.对α-受体的传统的解剖学分类已为药理学分类所取代;突触前受体参与信息的突触调节、非突触调节和跨突触调节;突触前-受体激活后可通过抑制神经末梢(膨体)的去极化程度和反应性或抑制膨体去极化-分泌耦联而抑制递质释放;突触前受体具有重要的生理意义和药理意义.
Since the early nineties formally named the presynaptic receptor, its development is extremely rapid.This article reviews the classification, function, mechanism of action, physiological significance and pharmacological significance of presynaptic adrenergic receptor (focusing on α-receptor) Some advances. The traditional anatomical classification of alpha-receptors has been superseded by pharmacological classification; presynaptic receptors are involved in synaptic, non-synaptic and trans-synaptic regulation of information; presynaptic-receptor Activation inhibits neurotransmitter release by inhibiting the degree of depolarization and reactivity of nerve endings (bulge) or inhibiting bulky depolarization-secretion coupling; presynaptic receptors have important physiological and pharmacological implications.