黄连素是一种具有丰富生物学活性的植物。近半个世纪以来,发现黄连素在体内外均具有一定程度的抗癌功效,能抑制肿瘤细胞的侵袭性,降低自发的和外界刺激诱导的肿瘤细胞增殖,干预耐药蛋白的表达,增加肿瘤细胞对传统放化疗的敏感性,影响多种基因的表达,从而实现对肿瘤增殖和转移的抑制。本文就介绍黄连素的抗癌功效及部分机制作一综述。 Berberine is a rich biological activity of plants. For nearly half a century, berberine has been found to have some degree of anticancer effect both in vivo and in vitro, inhibit the invasiveness of tumor cells, reduce spontaneous and external stimuli-induced proliferation of tumor cells, interfere with the expression of drug-resistant proteins, increase the tumor The sensitivity of cells to traditional radiotherapy and chemotherapy, affecting the expression of multiple genes in order to achieve the inhibition of tumor proliferation and metastasis. This article describes the anti-cancer effect of berberine and some mechanisms to be reviewed.