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尽管子宫内膜异位症(EMs)的病因不明确,其普遍可接受的病理生理学理论是经血逆流。但经血逆流只发生于部分EMs患者中,这提示EMs的发生还有其他因素。二噁英是指那些能与芳香烃受体结合、结构和性质相似的同类物或异构体的两大类有机化合物。二噁英能够增强雌激素作用,降低孕激素抑制子宫内膜异位的作用,促进T细胞表达、分泌CCL趋化因子(regulated on activation,normal T-cell expressed and secreted,Rantes)、子宫基质细胞金属蛋白酶(matrix metalloproteinase,MMP)、MMP-2、肿瘤坏死因子-α(TNF-α)。许多实验室和基于人群的研究表明,暴露于环境毒物也许是子宫内膜异位的诱因之一。
Although the etiology of endometriosis (EMs) is not clear, its generally accepted pathophysiological theory is menstrual blood flow. However, menstrual flow only occurs in some patients with EMs, suggesting that the occurrence of EMs and other factors. Dioxins are two major classes of organic compounds that are congeners, isomers or isomers that bind to aromatic hydrocarbon receptors in a similar structure and nature. Dioxins can enhance the role of estrogen, reduce the effect of progesterone on endometriosis, promote T cell expression, secrete CCL chemokines (regulators on activation, normal T-cell expressed and secreted, Rantes), uterine stromal cells Matrix metalloproteinase (MMP), MMP-2, tumor necrosis factor-α (TNF-α). Many laboratory and population-based studies have shown that exposure to environmental poisons may be one of the causes of endometriosis.