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目的探讨失笑散颗粒对异丙肾上腺素所致大鼠心肌损伤的保护作用。方法将心电图正常的Wistar健康大鼠随机分为6组(每组10只)。测定AST、CK-MB、CK、LDH、CPK、BNP、CRP、TnT。结果模型对照组大鼠的J值、AST、CK-MB、CK及LDH水平(0.199±0.132)MV、(203.43±32.81)、(80.72±27.53)、(398.37±47.26)、(400.17±128.37)U/L,明显高于空白对照组(P<0.05);与模型对照组相比,失笑散颗粒低剂量组能使心肌损伤大鼠的心电图J值下降值、AST、CK-MB、CK、LDH、CPK、BNP、CRP、TnT及LDH水平降低,差异无统计学意义(P>0.05),而中剂量组及高剂量组、阳性对照组均能使心肌损伤大鼠的心电图J值下降值、AST、CKMB、CK、LDH、CPK、BNP、CRP、TnT水平明显明显降低(P<0.05)。结论失笑散颗粒对异丙肾上腺素所致大鼠心肌缺血有明显的保护作用,能有效地减轻心肌损伤。
Objective To investigate the protective effect of Lixiao San Granule on myocardial injury induced by isoprenaline in rats. Methods Healthy Wistar rats with normal electrocardiogram were randomly divided into 6 groups (10 in each group). AST, CK-MB, CK, LDH, CPK, BNP, CRP, TnT were measured. Results The values of J, AST, CK-MB, CK and LDH in the model control group (0.199 ± 0.132) MV, (203.43 ± 32.81), (80.72 ± 27.53), (398.37 ± 47.26) and (400.17 ± 128.37) Compared with the model control group, Lixiao San Granule low-dose group could decrease the value of J, ECG, CK-MB, CK and CK in myocardial injury rats significantly (P <0.05) The levels of LDH, CPK, BNP, CRP, TnT and LDH in the rats with myocardial injury decreased significantly (P> 0.05), while those in the middle dose group, high dose group and positive control group could decrease the value of J The levels of AST, CKMB, CK, LDH, CPK, BNP, CRP and TnT were significantly decreased (P <0.05). Conclusion Lixiaosan Granule has obvious protective effect on isoproterenol-induced myocardial ischemia in rats, which can effectively reduce myocardial injury.