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目的:分析工业区居民砷暴露情况及影响因素，为保障工业区居民健康提供科学依据。方法:采用横断面调查法，于2017年，在兰州市西固区采集大气细颗粒物（PMn 2.5）、饮用水、土壤样本，检测砷含量，采用美国环保署推荐模型评估工业区环境砷暴露健康风险；抽取常住居民（包括成人、儿童青少年）进行尿砷和血砷含量检测，分析砷的内暴露水平及影响因素和砷与内、外暴露各因素的关系。砷含量均以几何均数表示。n 结果:共采集84份大气PMn 2.5样本，砷含量为7.53 ng/mn 3；共采集108份饮用水样本，砷含量为0.002 2 mg/L；共采集40份土壤样本，砷含量为0.14 mg/kg。工业区环境中砷的总非致癌风险商为0.39，低于非致癌风险商可接受水平（1.00）；总致癌风险为6.59 × 10n -5，其中以饮用水经口摄入途径贡献最大，呼吸吸入途径次之，分别占总致癌风险的78.60%[（5.18 × 10n -5）/（6.59 × 10n -5）]和20.79%[（1.37 × 10n -5）/（6.59 × 10n -5）]。共抽取常住居民135人，采集血样135份，血砷含量为0.92 μg/L，其中成人血砷含量（1.05 μg/L）高于儿童青少年（0.75 μg/L，n U = - 3.594，n P < 0.05）；采集尿样135份，尿砷含量为14.17 μg/L；尿砷与血砷水平呈正相关（ n r = 0.357，n P < 0.05）。血砷水平与总致癌风险，经呼吸、口和皮肤暴露的致癌风险均呈正相关（ n r = 0.252、0.244、0.255、0.255，n P均< 0.05）。n 结论:工业区环境中的砷元素对居民健康存在潜在的致癌风险，应限制居民饮用水经口途径和呼吸途径的砷摄入。“,”Objective:To analyze the arsenic exposure of industrial residents and its influencing factors, so as to provide scientific basis for protecting the health of industrial residents.Methods:In 2017, the samples of PMn 2.5, drinking water and soil were collected by using cross-sectional survey and were tested for arsenic contents in Xigu District, Lanzhou City. The environmental arsenic exposure was analyzed by using Environmental Protection Agency of USA health risk assessment models. The levels of urinary arsenic and blood arsenic were measured in residents who included adults, children and teenagers. The internal exposure level of arsenic and its influencing factors were analyzed. The correlation between arsenic and internal and external exposure factors were also analyzed. The content of arsenic was expressed by geometric mean.n Results:A total of 84 samples of PMn 2.5 were collected, and the content of air arsenic was 7.53 ng/mn 3. A total of 108 samples of drinking water were collected, and the content of water arsenic was 0.002 2 mg/L. A total of 40 samples of soil were collected, and the content of soil arsenic was 0.14 mg/kg. The total non-carcinogenic risk of environmental arsenic was 0.39, which was lower than the acceptable level of non-carcinogenic risk (1.00). The total carcinogenic risk of environmental arsenic was 6.59 × 10n -5. The total carcinogenic risk of arsenic was the highest through drinking water exposure and followed by the respiratory inhalation exposure, accounting for 78.60% [(5.18 × 10n -5)/(6.59 × 10n -5)] and 20.79% [(1.37 × 10n -5)/(6.59 × 10n -5)] of the total carcinogenic risk of environmental arsenic, respectively. There were 135 subjects, and 135 blood samples were collected. The content of blood arsenic was 0.92 μg/L. The level of blood arsenic of adults (1.05 μg/L) was higher than that of children and teenagers (0.75 μg/L, n U = - 3.594, n P < 0.05). One hundred and thirty-five urinary samples were collected, and the content of urinary arsenic was 14.17 μg/L. There was a positive correlation between urinary arsenic and blood arsenic ( n r = 0.357, n P < 0.05). Blood arsenic levels were positively correlated with the total carcinogenic risk and the risk of carcinogenesis through respiratory, oral and skin exposures ( n r = 0.252, 0.244, 0.255, 0.255, n P < 0.05).n Conclusion:Arsenic in the environment of industrial areas has a potential carcinogenic risk to the residents, so the intake of arsenic in drinking water through oral exposure and respiratory inhalation exposure should be limited.