在本世纪初,研究者们发现自由基能使脂肪酸败,这个重要的发现标志着自由基化学的开始。氧的正常利用对生命十分重要,当细胞内氧的利用异常,产生的氧自由基超过了机体的清除能力时,未被清除的自由基可诱发一系列反应,导致细胞损伤,引起疾病。本文拟就自由基的化学基础及与一些疾病的关系作一综述。一、化学基础(一)自由基的基本概念自由基是一个在其外层轨道上含有一个或多个不配对电子的分子、原子、原子团或离子。若这类物质含有不配对电子的 At the beginning of this century, researchers found that free radicals can defeat fatty acids. This important discovery marks the beginning of free radical chemistry. The normal utilization of oxygen is very important to life. When the intracellular oxygen utilization is abnormal and the produced oxygen free radicals exceed the ability of the body to scavenge, the not cleared free radicals can induce a series of reactions, leading to cell damage and disease. This article intends to review the chemical basis of free radicals and the relationship with some diseases. First, the chemical basis (a) the basic concept of free radicals Free radicals is a in its outer orbit contains one or more unpaired electrons of molecules, atoms, radicals or ions. If these substances contain unpaired electrons