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目的 探讨胰岛淀粉样多肽 (IAPP)在人胎胃的表达和定位。 方法 免疫组织化学SABC法对 12例 11～ 2 0周人胎胃体部IAPP免疫反应 (IR)细胞进行定位研究。 结果 人胎 11周 ,胃黏膜中已有IAPP IR细胞 ,主要定位于胃底腺。 14～ 2 0周 ,胃黏膜中IAPP IR细胞数量逐渐增多 ,免疫反应显色也逐渐加深。经与HE染色的邻片比较 ,部分IAPP IR细胞与壁细胞定位一致。 结论 IAPP IR细胞在人胎儿期已存在于胃体部。
Objective To investigate the expression and localization of islet amyloid polypeptide (IAPP) in human fetal stomach. Methods Immunohistochemical SABC method was used to determine the IAPP immunoreactive (IR) cells in 12 cases of human fetuses from 11 to 20 weeks. Results Human fetus 11 weeks, IAPP IR cells have been found in the gastric mucosa, mainly located in the fundic gland. In 14 ~ 20 weeks, the number of IAPP IR cells in gastric mucosa gradually increased, and the immunoreactivity was also gradually deepened. Compared with the adjacent HE staining, some IAPP IR cells were located in parietal cells. Conclusion IAPP IR cells have existed in the body of the stomach in human fetus.