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目的探讨核素骨显像在恶性淋巴瘤骨浸润中的临床应用价值。方法收集经病理证实的71例恶性淋巴瘤骨显像患者病例,其中霍奇金淋巴瘤(HL)8例,非霍奇金淋巴瘤(NHL)63例。经静脉注射99mTc-垭甲基二膦酸盐(99mTc-MDP)555-925 MBq后2．5-6h行全身骨显像检查。结果骨浸润病变者31例,其中8例HL中骨浸润3例,63例NHL中骨浸润28例。总病灶数103个,除2个骨放射性缺损外,101个浓聚灶分别为:脊柱35个(34．65％)、四肢骨及关节30个(29．70％)、肋骨14个(13．86％)、骨盆13个(12．87％)、颅骨5个(4．95％)及胸骨4个(3．96％)。结论核素骨显像在恶性淋巴瘤骨浸润的临床分期、治疗监测和预后转归等方面具有较高的临床价值。
Objective To investigate the clinical value of radionuclide bone imaging in the treatment of malignant lymphoma with bone infiltration. Methods Totally 71 patients with malignant lymphoma were enrolled in the study. Among them, 8 were Hodgkin lymphoma (HL) and 63 were non-Hodgkin’s lymphoma (NHL). Whole body bone imaging was performed 2.5 to 6 hours after intravenous injection of 99mTc-sodium methylideldiphosphonate (99mTc-MDP) 555-925 MBq. Results There were 31 patients with bone infiltration lesions, including 3 cases of HL infiltration in 8 cases and 28 cases of bone infiltration in 63 cases of NHL. The total number of lesions was 103, with the exception of two bone radiological defects. The 101 focal lesions were: 35 spondylolisthesis (34.65%), 30 limbs and joints (29.70%), 14 ribs .86%), pelvis 13 (12.87%), skull 5 (4.95%) and sternum 4 (3.96%). Conclusion Radionuclide bone imaging has high clinical value in clinical stage, treatment monitoring and prognosis of malignant lymphoma with bone infiltration.