由EPA/IARC公布的448种化学物质的诱变试验结果中,经30种以上方法测试的化学物质共有60种。通过MCT对这些物质的诱变终点分析,没有发现能对各种方法均产生阳性结果的化学物质。经两两比较,显示这些化学物质的诱变终点也有很大差别。黄曲霉毒素B_1等有较广泛的诱变终点,而放线菌素D等的诱变终点较为特异。用CASE对其中10种致癌剂分子结构作了分析,提示可能与关键片段不同有关。因此建议在选择筛选方法和阳性对照物时,应该慎重,以免遗漏所谓“窄谱”致癌剂。 According to the results of the mutagenesis test of 448 chemical substances published by EPA/IARC, there are a total of 60 chemical substances tested by more than 30 methods. The mutagenesis endpoint analysis of these substances by MCT revealed no chemical substances that could produce positive results for various methods. After comparing the two, it was shown that the mutagenic end points of these chemicals are also very different. Aflatoxin B 1 has a wide range of mutagenesis endpoints, while actinomycin D and other mutagenic endpoints are more specific. The structure of 10 carcinogens was analyzed by CASE, suggesting that it may be related to different key fragments. It is therefore recommended that when selecting screening methods and positive controls, care should be taken to avoid missing the so-called “narrow-spectrum” carcinogens.