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超高压光子放射治疗中,皮肤耐受量很少是一限制剂量因素。但在照射野重叠和使用带电粒子束(常使用单个照射野)等情况下,皮肤耐受量仍是一个剂量限制因素。为探索用局部使用抗放剂来提高皮肤耐受量的可能性,作者用雌雄各半、约12周大的无特殊病原体限定群的C_3Hf/Sed 小鼠研究了局部运用MEA(β-巯基乙胺或半胱氨酸)、WR2721和N-乙酰半胱氨酸(NAC)对小鼠皮肤的抗放效应;同时也研究了皮肤的氧浓度对经缓冲的MEA 的抗放效应的影响。实验用~(137)Cs 照射鼠右后腿,实验前8天拔除右后腿毛、使毛囊反应同步化。照射前用浸饱生理盐水的棉纱包裹后腿15分钟,以增加皮肤角化层的渗透能力。然后再分别换为浸饱MEA、WR2721和NAC 溶液的棉纱浸泡15分钟(对照组续用盐纱再15分钟)同时分别另设一浸泡60分
In ultra-high pressure photon radiotherapy, skin tolerability is rarely a limiting dose factor. However, skin toleration is still a dose limiting factor in the case of overlapping radiation fields and the use of charged particle beams (usually using a single radiation field). To explore the possibility of using topical antiresin to increase skin tolerability, the authors studied the topical use of MEA (β-thiomethamphetamine) in male and female, about 12 weeks old C3Hf/Sed mice with no specific pathogen-defining population. (Amine or cysteine), WR2721, and N-acetylcysteine (NAC) have anti-irradiation effects on mouse skin; the effect of skin oxygen concentration on the anti-radiation effect of buffered MEA was also studied. The rats were irradiated with ~(137)Cs on the right hind leg. The right hind leg hairs were removed 8 days before the experiment to synchronize the hair follicle reaction. Before the irradiation, the hind legs were wrapped with saline-soaked cotton yarn for 15 minutes to increase the penetration ability of the keratinized layer of the skin. Then they were replaced with cotton yarns that were saturated with MEA, WR2721, and NAC solutions for 15 minutes (the control group continued to use salted yarn for another 15 minutes) and they were each soaked for another 60 minutes.