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胶霉毒素(gliotoxin,GT),又称胶毒素,是真菌代谢产物(epipolythiodioxopiperazine,ETP)家族中的一员,最早从粘帚霉(gliocladium)中分离得到,并因此得名。胶霉毒素是烟曲霉(Aspergillus fumigatus)的代谢真菌毒素之一,后者是侵袭性曲霉病(invasive aspergillosis,IA)最常见的病原菌[1],可产生多种免疫抑制性真菌毒素,例如GT、烟曲霉素、烟曲霉酸、烟曲霉溶血素等。胶霉毒素作为最主要和最强
Gliotoxin (GT), also known as gelatinotoxin, is a member of the epipolythiodioxopiperazine (ETP) family and was first isolated from gliocladium and hence its name. Gliotoxin is one of the metabolic mycotoxins of Aspergillus fumigatus, the most common pathogen of invasive aspergillosis (IA) [1] and produces a variety of immunosuppressive mycotoxins such as GT Fumagillin, fumagillic acid, fumagillin, and the like. Gliotoxin as the most important and strongest