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为了观察化呆醒神汤对血管性痴呆大鼠行为学的影响 ,使用改良的四血管法复制成功血管性痴呆(VD)大鼠 ,术后当天即开始使用化呆醒神汤 (中药治疗组 )和喜得镇 (西药对照组 )治疗 ,行为学实验表明 ,化呆醒神汤和喜得镇两治疗组均能明显缩短水迷宫试验中游全程时间 ,减少进入盲端错误次数 ,改善VD大鼠空间学习辨别能力 ,且中、西药组相比无显著性差异 :在跳台和避暗试验中 ,两治疗组均能显著延长逃避潜伏期 ,明显减少错误次数 ,且在跳台试验中 ,中药组效果优于西药组 ,在避暗试验中 ,中、西药组相比无显著性差异。由此可见 ,化呆醒神汤可显著改善VD大鼠学习记忆障碍。
In order to observe the effect of Huaxing Shenxue Decoction on the behavior of vascular dementia rats, a rat model of vascular dementia (VD) was successfully modified using a modified four-vessel method. The Huadeng Xingshen Decoction was used on the day after the operation. ) and Xideng (Western medicine control group) treatment, behavioral experiments show that Huadu Xingshen Decoction and Xideng two treatment groups can significantly reduce the water maze test midstream time, reduce the number of errors into the blind end, improve VD There was no significant difference in the spatial learning ability of rats, and there was no significant difference between the Chinese and Western medicine groups. In both the platform and dark test, the two treatment groups could significantly prolong the escape latency and significantly reduce the number of errors, and in the step-down test, the effect of the Chinese medicine group. Compared with the Western medicine group, in the dark test, there was no significant difference between the Chinese medicine group and western medicine group. This shows that Huadow Xingshen Decoction can significantly improve learning and memory impairment in VD rats.