简介:本文通过对过去二十年内没有接种过白喉和破伤风相关疫苗的成人给予单剂量Tdap-IPV(破伤风、白喉、百日咳和灭活脊髓灰质炎疫苗)和两剂Td-IPV(破伤风、白喉和灭活脊髓灰质炎疫苗),来评价这两种疫苗的免疫原性与安全性。方法:开放性标记试验和多中心试验均在年龄 INTRODUCTION: This study examined the effects of Tdap-IPV (tetanus diphtheria, pertussis and inactivated polio vaccine) and two doses of Td-IPV (tetanus toxoid) on adults who had not been vaccinated against diphtheria and tetanus during the past two decades Diphtheria and inactivated polio vaccine) to evaluate the immunogenicity and safety of both vaccines. Methods: Open-label and multicenter trials were all at age