论文部分内容阅读
目的探讨MUC1及MMP-7在ESCC发生发展中的作用及其临床意义。方法应用免疫组化(IHC)法测定84例癌组织及22例相应癌旁组织标本中MUC1和MMP-7蛋白表达水平,并分析其与临床病理资料之间的关系。结果 ESCC癌组织标本中MUC1和MMP-7的阳性表达率分别为66.67%(56/84)和53.57%(45/84),癌旁组织阳性表达率分别为18.18%(4/22)和4.55%(1/22)相比,差异均有统计学意义(P<0.01);MUC1与MMP-7表达呈显著正相关(r=0.608,P<0.01)。结论 MUC1和MMP-7在ESCC中高表达,可能与ESCC发展及侵袭转移有关。
Objective To investigate the role of MUC1 and MMP-7 in the development of ESCC and its clinical significance. Methods The expressions of MUC1 and MMP-7 in 84 cases of cancerous tissue and 22 cases of corresponding paracancerous tissues were detected by immunohistochemistry (IHC), and their relationship with clinical pathological data was analyzed. Results The positive rates of MUC1 and MMP-7 in ESCC tissues were 66.67% (56/84) and 53.57% (45/84), respectively. The positive rates of MUC1 and MMP-7 in paracancerous tissues were 18.18% (4/22) and 4.55 % (1/22) respectively. There was a significant positive correlation between the expression of MUC1 and MMP-7 (r = 0.608, P <0.01). Conclusion The high expression of MUC1 and MMP-7 in ESCC may be related to the development of ESCC and the invasion and metastasis of ESCC.