论文部分内容阅读
目的探讨持续性糖皮质激素吸入疗法治疗儿童支气管哮喘的疗效及对患儿骨密度及骨代谢的影响。方法选取支气管哮喘儿童66例作为治疗组,并随机分为A、B两组,治疗组持续糖皮质激素吸入治疗1.5年,A组给予丙酸倍氯米松气雾剂治疗,B组给予布地奈德气雾剂治疗,同期体检正常的40例儿童作为对照组。观察3组肺功能变化,检测并比较骨密度和骨代谢指标。结果治疗后A、B两组的FEV1和FEV1/FVC显著高于治疗前(P<0.01),但组间比较差异无统计学意义(P>0.05);治疗后A、B两组血钙、血磷、碱性磷酸酶、尿钙与尿肌酐比、骨密度和24 h游离皮质醇较治疗前和对照组均无明显变化(P>0.05),且3组儿童身高和体重增加亦无明显差异(P>0.05)。结论支气管哮喘儿童长期持续吸入治疗剂量糖皮质激素疗效显著,安全性高,并对其生长发育无不良影响。
Objective To investigate the effect of continuous glucocorticoid inhalation therapy on children with bronchial asthma and its effect on bone mineral density and bone metabolism in children. Methods Sixty-six children with bronchial asthma were selected as the treatment group and were randomly divided into A and B groups. The treatment group was treated with inhaled glucocorticosteroids for 1.5 years. A group was treated with beclometasone dipropionate aerosol. Group B was given budesonide De aerosol treatment, check the same period 40 cases of normal children as a control group. The changes of lung function in 3 groups were observed, and the bone mineral density and bone metabolism indexes were detected and compared. Results The FEV1 and FEV1 / FVC of A and B groups after treatment were significantly higher than those before treatment (P <0.01), but there was no significant difference between the two groups (P> 0.05) The levels of serum phosphorus, alkaline phosphatase, ratio of urinary calcium to urinary creatinine, bone mineral density and 24 h free cortisol had no significant difference (P> 0.05) compared with before treatment and control group, and there was no significant difference in height and weight between the three groups Difference (P> 0.05). Conclusion Long-term sustained inhalation of bronchial asthma in children treated with a dose of glucocorticoid significant effect, high safety, and its growth and development without adverse effects.