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Background: Rapid sequence intubation (RSI) is an advanced airway management medical procedure used to achieve tracheal intubation under general anesthesia in patients who are at high risk of pulmonary aspiration. Succinylcholine is a common medication used during RSI with paralytic aim. On the other hand, Magnesium sulfate also has muscular relaxant effect. The aim of this study is the efficiency of magnesium sulfate instead of succinylcholine in RSI process will be studied.Methods: This single blind clinical trial contained 90 patients divided into 2 equal groups. Group 1 received succinylcholine based on usual process of RSI and Group 2 received magnesium sulfate at preoxygenation step of RSI without succinylcholine injection. Heart rate, systolic and diastolic blood pressure for each patient had been measured at 6 different times. Obtained results were analyzed by SPSS ver. 22.Results: The results showed significant reduction of the heart rate in all patients (P < 0.05). The heart rate of both groups at corresponding time were also compared and it had significant differences in most of critical times. These results also repeated for systolic and diastolic blood pressure. The excellent acceptability and quality of intubation in group 1 was higher rather than group 2, but statistical analysis did not show any significant differences between them (P >0.05).Conclusion: Based on the obtained results in this study, it can be concluded that using succinylcholine or magnesium sulfate in RSI process has same effect on intubation outcome.