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目的:探讨经腹单纯子宫全切除术对绝经前妇女卵巢内分泌功能的影响。方法:采用放射免疫法对60例因子宫肌瘤而行经腹子宫全切除术且保留双侧附件、年龄45岁以下的绝经前妇女,术后半年及1年测定血清FSH、LH、E2水平,并分别与对照组比较,同时采用问卷对术后围绝经期症状和性生活的影响进行调查。结果:术后半年血清FSH、LH、E2水平与对照组比较差异无统计学意义(P>0.05);术后1年血清FSH水平升高,血清E2水平下降,与对照组比较差异均有统计学意义(P<0.05)。结论:绝经前妇女单纯子宫全切除术对卵巢内分泌功能有一定程度的影响。对于年龄45岁以下的绝经前子宫肌瘤患者应权衡利弊,慎重行子宫全切除术。
Objective: To investigate the effect of transabdominal simple hysterectomy on ovarian endocrine function in premenopausal women. Methods: 60 cases of uterine fibroids underwent total abdominal hysterectomy with bilateral attachment, premenopausal women aged below 45 years old by radioimmunoassay. Serum FSH, LH and E2 levels were measured at 6 and 1 year after operation. And compared with the control group, at the same time using the questionnaire postmenopausal symptoms and sexual life were investigated. Results: The levels of serum FSH, LH and E2 in six months after operation were not significantly different from those in control group (P> 0.05). The level of serum FSH increased 1 year after operation and the level of serum E2 decreased, compared with the control group Significance (P <0.05). Conclusions: Simple hysterectomy in premenopausal women has a certain degree of effect on ovarian endocrine function. For 45 years of age before the age of menopausal uterine fibroids patients should weigh the pros and cons, cautious hysterectomy.