已知钩端螺旋体(简称钩体)疫苗能预防钩端螺旋体病(简称钩体病),然而血清型特异性限制了全菌体灭活疫苗的效力。正在寻找能诱导抗各血清型交叉保护性免疫的钩体抗原。已在致病性钩体中找到保守性抗原,这些抗原能在动物模型中诱导保护性免疫。随着两株钩体全长基因组的破译,已应用反向疫苗学来鉴定钩体候选疫苗。 Leptospira known leptospirosis Vaccine can prevent leptospirosis (referred to leptospirosis), however, serotype specificity limits the efficacy of whole body inactivated vaccine. Leptospira antigens that are able to induce cross-protective immunity against each serotype are being sought. Conserved antigens have been found in pathogenic leptons that can induce protective immunity in animal models. As the entire length of the two leptospira genomes has been deciphered, reverse vaccines have been used to identify leptospira vaccine candidates.