论文部分内容阅读
最近肌丙抗增压素(Saralasin)用于高血压的鉴别诊断和治疗引起各方重视,该剂为类似天然缩血管物质血管紧张素Ⅱ,但第1、8位氨基酸被取代的合成药物。在体内它能与紧张素Ⅱ受体结合但缩血管效应十分微弱,其药理作用随血循环紧张素Ⅱ含量多寡而异,血管紧张素Ⅱ高浓度时该剂与其竞争受体抑制前者的缩血管效应使血压降低。当前者低浓度时该剂与其受体结合又起部分升压效应,即具有双重作用。由于该剂是
Recently, the use of muscle-specific anti-Saralasin for the diagnosis and treatment of hypertension has attracted much attention. This agent is a synthetic drug that resembles the natural vasoconstrictor angiotensin II but has amino acids 1 and 8 substituted. It binds to the receptor of angiotensin II in the body, but its vasoconstrictor effect is very weak. Its pharmacological action varies with the level of circulating angiotensin Ⅱ. In the high concentration of angiotensin Ⅱ, the agent and its competitive receptor inhibit the vasoconstrictive effect of the former Reduce blood pressure. The current low concentration of the agent with its receptor and part of the boost effect, which has a dual role. Because the agent is