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目的研究甜菜宁对大鼠的亚慢性毒性,求出最大无作用剂量。方法SD健康大鼠80只,随机分4组,每组20只,按照GB 15670-1995《农药登记毒理学试验方法》进行试验。结果5 000 mg／kg饲料组增重、食物利用率明显低于对照组,肺／体比、脾／体比、肝／体比高于对照组,15 000 mg／kg饲料组总摄食量、增重、食物利用率明显低于对照组,脑／体比、脾／体比、肝／体比、胸腺／体比高于对照组。病理组织学检查显示5 000、15 000 mg／kg饲料组肾、肺的病变率较高。结论甜菜宁的最大无作用剂量为雌性大鼠(133．06±13．11)mg/(kg·d),雄性大鼠(121．52±13．29)mg／(kg·d)。
Objective To study the subchronic toxicity of beet in rats and to find the maximum non-action dose. Methods Eighty healthy SD rats were randomly divided into 4 groups (20 in each group). The test was conducted according to GB 15670-1995 “Toxicological Test of Pesticide Registration”. Results The weight gain and food utilization rate of the 5 000 mg / kg diet group were significantly lower than those of the control group. The lung / body ratio, spleen / body ratio, liver / body ratio were higher than those of the control group and 15 000 mg / Weight gain, food utilization rate was significantly lower than the control group, brain / body ratio, spleen / body ratio, liver / body ratio, thymus / body ratio higher than the control group. Histopathological examination showed that the incidence of renal and pulmonary lesions was higher in the 5 000 and 15 000 mg / kg feed groups. Conclusion The maximum untreated dose of beet noton is 133.06 ± 13.11 mg / (kg · d) in female rats and 121.52 ± 13.29 mg / (kg · d) in male rats.