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目的研究甲氨蝶呤联合米非司酮治疗宫外孕和的临床疗效。方法选择笔者所在医院2008年4月～2011年1月期间收治的符合保守治疗要求的宫外孕患者127例。随机分成A、B、C三组,A组40例单独使用甲氨蝶呤治疗,B组40例单独使用米非司酮治疗,C组47采用两药联合治疗,比较三组患者的临床疗效和不良反应发生情况。结果甲氨蝶呤和米非司酮单独使用,其临床疗效差异不大(P>0.05),联合使用两种药可以明显提高患者的临床疗效(P<0.05);在不良反应发生情况方面,联合用药组发生率最低,只有8.5%,其次米非司酮组,32.5%,最后是甲氨蝶呤组,60.0%,三者比较差异具有统计学意义(P<0.05)。结论联合用药可以提高宫外孕患者的临床疗效,降低不良反应发生,具有较高的临床使用价值。
Objective To study the clinical efficacy of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods Select the author’s hospital in April 2008 ~ January 2011 period in line with conservative treatment requirements of 127 cases of ectopic pregnancy. 40 patients in group A were treated with methotrexate alone, 40 patients in group B were treated with mifepristone alone, and 47 patients in group C were treated with two drugs in combination. The clinical efficacy of the three groups was compared And adverse reactions occurred. Results Methotrexate and mifepristone alone had little difference in clinical efficacy (P> 0.05). The combination of two drugs can significantly improve the clinical efficacy (P <0.05). In the aspect of adverse reactions, The incidence of combination group was the lowest, only 8.5%, followed by mifepristone group, 32.5%, and finally methotrexate group, 60.0%, the difference was statistically significant (P <0.05). Conclusion Combination therapy can improve the clinical efficacy of patients with ectopic pregnancy, reduce the incidence of adverse reactions, with high clinical value.