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目的探讨环状RNA(ciRS-7)表达及其在喉鳞状细胞癌中的预后价值。方法利用real-timePCR技术检测我院32例喉鳞状细胞癌组织及癌周围正常组织ciRS-7的表达。结果与癌周围正常组织相比喉鳞状细胞癌的ciRS-7呈现高表达。临床分期、吸烟史、浸润程度、淋巴结转移和远处转移均已被证实影响ciRS-7的表达(P<0.05)。Kaplan-Meier分析结果显示ciRS-7表达水平高的患者生存时间短于ciRS-7表达低的患者(P<0.01)。通过Cox回归分析ciRS-7对预后评估有价值。结论 ciRS-7与喉鳞状细胞癌的预后密切相关,ciRS-7在喉鳞状细胞癌组织中上调,可能是喉鳞状细胞癌患者的独立预后指标。
Objective To investigate the expression of ciRS-7 and its prognostic value in laryngeal squamous cell carcinoma. Methods Real-time PCR was used to detect the expression of ciRS-7 in 32 cases of laryngeal squamous cell carcinoma and normal tissues around cancer. Results The expression of ciRS-7 in laryngeal squamous cell carcinoma was higher than that in normal tissues around the tumor. Clinical stage, smoking history, degree of infiltration, lymph node metastasis and distant metastasis have been confirmed to affect ciRS-7 expression (P <0.05). Kaplan-Meier analysis showed that patients with high expression of ciRS-7 had shorter survival time than those with low ciRS-7 expression (P <0.01). Analysis of ciRS-7 by Cox regression is valuable for prognostic assessment. Conclusions ciRS-7 is closely related to the prognosis of laryngeal squamous cell carcinoma. CiRS-7 is up-regulated in laryngeal squamous cell carcinoma and may be an independent prognostic factor for laryngeal squamous cell carcinoma.