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目的:探讨胃肠舒促胃肠动力的作用机制。方法:选择SD大白鼠随机分为正常对照组、左旋精氨酸(L-Arg)对照组、L-Arg加西沙比利组、L-Arg加胃肠舒组。除正常对照组外,其余3组ip盐酸左旋精氨酸,各组分别给等容积的受试药物ig,眼底球后静脉采血,放射免疫法测定血浆胃动素(MTL),硝酸还原酶法测定血清一氧化氮(NO)。结果:L-Arg加胃肠舒组较L-Arg对照组血浆MTL显著升高(P<0.05),血清NO显著降低(P<0.01)。结论:胃肠舒促胃肠动力的作用机制可能是通过升高血浆MTL和降低血清NO含量,使胃肠平滑机细胞内Ca2+浓度增加,Ca2+信号系统引发一系列生理功能,而促进胃肠平滑肌收缩效应。
Objective: To explore the mechanism of gastrointestinal motility promoting gastrointestinal motility. METHODS: SD rats were randomly divided into normal control group, L-arginine (L-Arg) control group, L-Arg plus cisapride group, L-Arg plus Weishushu group. In addition to the normal control group, the remaining 3 groups were given ip arginine hydrochloride, each group was given an equal volume of the test drug ig, blood was collected from the fundus of the fundus, and plasma motilin (MTL) was measured by radioimmunoassay. Serum nitric oxide (NO) was measured. RESULTS: Compared with L-Arg control group, L-Arg plus Gastrointestinal control group had significantly higher plasma MTL (P<0.05), and serum NO significantly decreased (P<0.01). Conclusion: The mechanism of gastrointestinal motility promotes gastrointestinal motility may be through increasing plasma MTL and decreasing serum NO levels, so that the intracellular Ca2+ concentration in gastrointestinal smoothing machine is increased. Ca2+ signaling system initiates a series of physiological functions and promotes gastrointestinal smooth muscle. Shrinkage effect.