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目的：研究心肌缺血再灌注时人体外周血中性粒细胞（ＰＭＮ）的数量、ＰＭＮ聚集率、内皮素（ＥＴ）、脂质过氧化物（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）及过氧化氢酶（ＣＡＴ）的变化，并观察前列腺素Ｅ１（ＰＧＥ１）对心肌缺血再灌注损伤的保护作用。方法：将３６例急性心肌梗死患者随机分为２组，每组１８例。治疗组给予ＰＧＥ１加尿激酶和硝酸甘油静滴，对照组给予尿激酶和硝酸甘油静滴，于再灌注前后分别采静脉血测定上述指标。结果：心肌缺血时外周血ＰＭＮ数量无显著增多，但ＰＭＮ活性显著增强，血ＥＴ及ＬＰＯ水平增高，血ＳＯＤ和ＣＡＴ活性下降；再灌注后，ＰＭＮ数量无明显增多（Ｐ均＞０．０５），但ＰＭＮ活性进一步显著增强，ＥＴ及ＬＰＯ水平进一步显著增高，而ＳＯＤ和ＣＡＴ活性则进一步显著下降。使用ＰＧＥ１治疗后结果则与上述情况相反。结论：ＰＭＮ及ＥＴ在心肌缺血再灌注损伤过程中起重要作用，ＰＧＥ１可以抑制ＰＭＮ活性，保护ＳＯＤ和ＣＡＴ活性，减少ＥＴ及ＬＰＯ产生，减轻过氧化反应，对心肌缺血再灌注损伤有显著的保护作用。
Objective: To study the changes of PMN, PMN accumulation, ET, LPO, SOD in myocardial ischemia-reperfusion and Catalase (CAT) changes, and observe the protective effect of prostaglandin E1 (PGE1) on myocardial ischemia-reperfusion injury. Methods: Thirty-six patients with acute myocardial infarction were randomly divided into two groups with 18 cases in each group. The treatment group was given PGE1 plus intravenous infusion of urokinase and nitroglycerin, the control group was given intravenous infusion of urokinase and nitroglycerin, before and after reperfusion venous blood were collected to measure the above indicators. Results: There was no significant increase of PMN in myocardial ischemia, but the activity of PMN was significantly increased, the levels of ET and LPO were increased, while the activities of SOD and CAT were decreased. However, the numbers of PMN were not significantly increased after reperfusion ), PMN activity was further significantly enhanced, ET and LPO levels were significantly increased, while SOD and CAT activity was further significantly decreased. The result after treatment with PGE1 is the opposite of the above. CONCLUSION: PMN and ET play an important role in the process of myocardial ischemia-reperfusion injury. PGE1 can inhibit the activity of PMN, protect the activities of SOD and CAT, reduce the production of ET and LPO, alleviate the peroxidation and have a significant effect on myocardial ischemia-reperfusion injury The protective effect.