HLA-G被推测能帮助细胞或组织逃脱免疫监视和排斥反应,实现免疫耐受和逃逸[1]。但也有一些证据持相反观点[2,3]。因而,其功能的明确和对其发挥功能的机制的深入研究,对实现移植耐受和有效的肿瘤治疗具有重要意义。本研究中,建立了抗HLA-G单克隆抗体(mAb)的杂交瘤细胞株,命名为G HLA-G is hypothesized to help cells or tissues escape immune surveillance and rejection and achieve immune tolerance and escape [1]. But there is some evidence to the contrary [2,3]. Therefore, a clear study of its function and mechanism of its function is of great significance for the realization of transplantation tolerance and effective tumor treatment. In this study, we established a hybridoma cell line that is an anti-HLA-G monoclonal antibody (mAb) named G