前言自从环戊醚乙炔雌二醇被证实为长效雌激素以后,由于付作用太大,不能单独用作长效避孕药物。为了进一步寻找药效长、付作用小的避孕药物,对孕激素的结构改造方面,曾作了大量的工作。早在1956年 F.Sondheimer 等以及后来 J.C.Babcock 等、Upjohn 工厂合成了 17--羟基黄体酮的长链羧酸酯类化合物。 Introduction Since pentaminyl estradiol has been shown to be a long-acting estrogen, it can not be used alone as a long-acting contraceptive since it is too potent. In order to further find effective and pay small contraceptives, a great deal of work has been done on the structural transformation of progesterone. As long ago in 1956 F..Sondheimer et al., And later J.C.Babcock et al., Upjohn factory synthesis of 17 - hydroxyl progesterone long chain carboxylic acid ester compounds.