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在狂犬病病毒各种结构蛋白中,糖蛋白是研究最广泛、最深入的一种蛋白质。它是狂犬病毒5个结构蛋白中,惟一能刺激机体产生中和抗体的抗原,与狂犬病病毒的多种生物学特性有关。根据其自身特性,狂犬病病毒糖蛋白已经应用在多个领域。本综述在系统介绍狂犬病病毒糖蛋白结构和功能的基础上,阐述其在疫苗研制、抗原抗体检测中的应用。
In various structural proteins of rabies virus, glycoprotein is the most extensively studied and most in-depth protein. It is the only one of the five structural proteins of rabies virus that can stimulate the body to produce neutralizing antibodies and is associated with a variety of biological characteristics of rabies virus. According to its own characteristics, rabies virus glycoprotein has been used in many fields. This review introduces systematically the structure and function of rabies virus glycoprotein, and expounds its application in vaccine development and antigen-antibody testing.