【摘 要】
:
The interaction of small molecules with lipid membranes and the exact knowledge of their binding site and bilayer distribution is of great pharmacological impor
【机 构】
:
Junior Research Group “Structural Biology of Membrane Proteins”,Institute of Biochemistry/Biotechnol
论文部分内容阅读
The interaction of small molecules with lipid membranes and the exact knowledge of their binding site and bilayer distribution is of great pharmacological impor-tance and represents an active field of current biophysical research. Over the last decade, a highly resolved 1H solid-state NMR method has been developed that allows measuring localization and distribution of small molecules in membranes. The classical solution 1H NMR NOESY technique is applied to lipid membrane samples under magic-angle spinning (MAS) and NOESY cross-relaxation rates are determined quantitatively. These rates are proportional to the contact probability between molecular segments and therefore an ideal tool to study intermolecular interactions in membranes. Here, we review recent 1H MAS NOESY applications that were carried out to study lateral lipid organization in mixed membranes and the interaction of membranes with water, ethanol, small aromatic compounds, peptides, fluorescence labels, and lipophilic nucleosides.
其他文献
Aim:It has been reported that stem cells are able to home to tumorigenesis and inhibit the proliferation of tumor cells.The purpose of our study was to demon-st
本文利用花粉管通道法将外源DNA(大豆)导入玉米自交系,后代产生了多种多样的变异类型,变异性状十分丰富,这些变异性状有的具有供体性状,有的产生新的性状,通过对其后代农艺性状观察、叶绿素含量测定、过氧化物同工酶酶谱、营养指标测定等分析。具体结果如下:1)提取供体(高蛋白大豆富锦J05-2-075)的总DNA,配成500μg/ml浓度,分别在受体(普通玉米自交系7313)自交授粉后22h、24h、26
Aim:To examine how the sarcoplasmic reticulum (SR) Ca2+ content changes and the underlying mechanism in L-thyroxin-induced cardiac hypertrophy. Methods:Echocard
MRI常规扫描凭借着较高的软组织分辨率对宫颈癌肿块在宫颈内部的生长情况、肿块对宫体的侵犯程度以及对宫旁癌周的侵犯、宫旁闭孔区淋巴结转移的评价方面具有较高准确性和特
Aim: To determine whether extracellular or intravascular contrast agents could detect chronic scarred myocardium in magnetic resonance imaging (MRI). Methods: E
为明确不同优势玉米杂交种密植群体光能、氮素利用特征与物质生产及其产量的关系,本文以不同杂优模式品种郑单958(ZD958,Reid×唐四平头模式)和先玉335(XY335,Reid×Lancaste
0606820 机载设备ATE通用自动计量系统的设计与开发[刊, 中]/纪明霞//计算机测量与控制.-2005,13(12).- 1348-1350(C) 介绍了采用VXI-GPIB混合总线方式的机载ATE 计量校准系统
杂种优势是生物界的普遍现象,杂种优势的利用推动了作物产量和品质的大幅度提高。为了更有效地利用杂种优势现象为人类服务,必须从理论上揭示杂种优势形成的机理,围绕杂种优势的形成原因,国内外学者作了大量的理论探讨,取得一些积极进展。 油菜是世界范围内广泛种植的主要油料作物之一。我国油菜种植面积和总产约占世界的1/3,均居世界首位,其中杂交种种植面积超过栽培总面积的50%。但是传统的亲本选配方法人力、