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OX4 0 /OX4 0L是T APC应答过程中的一对重要的协同刺激分子。当T细胞上的OX4 0与APC上的OX4 0L结合 ,OX4 0就将一个协同刺激信号传递给T细胞 ,促进了细胞克隆的扩增和增强其效应功能。OX4 0主要作用于T细胞效应的晚期阶段 ,能促进更多的记忆T细胞生成。在疾病过程中 ,OX4 0仅表达在炎症浸润部位的抗原特异性CD4 + T细胞上 ,因此可为临床诊断和疾病治疗提供依据 ,而且可能成为免疫干预疾病的理想模式
OX4 0 / OX4 OL is a pair of important costimulatory molecules in T APC response. When OX4 0 on T cells binds to OX4 OL on APC, OX4 0 delivers a costimulatory signal to T cells, promoting the expansion of cell clones and enhancing their effector functions. OX4 0 acts mainly in the later stages of T cell effects and promotes more memory T cells. OX4 0 is expressed only on antigen-specific CD4 + T cells at the site of inflammatory infiltration during disease, and may therefore provide the basis for clinical diagnosis and treatment of disease and may be an ideal model for immunological intervention