Skp2属于泛素蛋白酶系统的识别亚单位,通过特异性识别蛋白底物,介导各种细胞周期调控因子的泛素化降解,促进细胞周期向S期进展,从而参与对细胞周期的调控。细胞周期蛋白依赖性激酶抑制物(CDKI)作为细胞周期负性调控因子在维持细胞周期正常运行方面起着关键作用。p27属于细胞周期蛋白激酶抑制物的一种,抑制细胞通过细胞周期监测点,阻滞细胞生长,防止细胞过度增殖,在稳定细胞正常生理状态方面具有重 Skp2 belongs to the recognition subunit of ubiquitin protease system. It can regulate the cell cycle by specifically recognizing protein substrates, mediating the ubiquitination degradation of various cell cycle regulators and promoting the progression of cell cycle to S phase. Cyclin-dependent kinase inhibitors (CDKIs) play key roles as cell cycle negative regulators in maintaining normal cell cycle. p27 is a member of the cyclin kinase inhibitor that inhibits cell passage through the cell cycle checkpoint, arrests cell growth, prevents cell hyperproliferation, and has a potent ability to stabilize normal cell physiology