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肥胖是男性生殖功能低下的危险因素,运动是改善肥胖所致男性生殖功能低下的重要手段,但不同负荷运动及其运动后的恢复训练对肥胖男性生殖功能低下的影响却值得探究。方法:80只雄性C57BL/6J小鼠随机被分为标准饲料对照组(NC)、肥胖对照组(OC)、肥胖中等负荷运动组(OME)、肥胖大负荷运动组(OHE)、标准饲料恢复组(NR)、肥胖恢复组(OR)、肥胖中等负荷运动恢复训练组(OMER)、肥胖大负荷运动恢复训练组(OHER)。OME组和OMER组进行8周,2 h/d,6 d/周的游泳运动。OHE组和OHER组每天进行2次OME组或OMER组的游泳运动。OMER组和OHER组8周运动干预结束后,再进行恢复性游泳训练,1 h/天,6 d/周,4周后结束。末次运动24 h后测量体长、体重、腹腔脂肪重量、生殖腺重量(睾丸、附睾、精囊腺),测定血清黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)浓度,显微镜下测定精子浓度和精子活力。结果:肥胖会造成雄性小鼠生殖功能的下降。中等负荷运动和大负荷运动均能显著降低小鼠肥胖程度,且大负荷运动减肥效果更好,但只有中等负荷运动能显著逆转肥胖所致雄性小鼠生殖腺系数、血清性激素水平和精液质量参数的下降。恢复性训练能进一步恢复中等负荷运动后肥胖雄性小鼠的生殖功能,但不能改善大负荷运动后肥胖雄性小鼠生殖功能的低下。结论:中等负荷运动及中等负荷运动后再进行恢复性训练均能显著改善肥胖所致雄性小鼠生殖功能的低下,而大负荷运动和大负荷运动后再进行恢复性训练均不能有效改善肥胖所致雄性小鼠生殖功能的低下。
Obesity is a risk factor for male reproductive dysfunction. Exercise is an important means to improve obesity-induced male reproductive dysfunction. However, it is worth exploring for the effect of different exercise and post-exercise training on obesity in obese men. Methods: Eighty male C57BL / 6J mice were randomly divided into standard feed control group (NC), obese control group (OC), obese moderate load exercise group (OME), obese heavy load exercise group (OHE) (NR), obesity recovery group (OR), obese middle-weight exercise recovery training group (OMER) and obese heavy-weight exercise recovery training group (OHER). OME group and OMER group for 8 weeks, 2 h / d, 6 d / week of swimming. The OHE group and the OHER group performed swimming twice a day in the OME group or the OMER group. OMER group and OHER group after 8 weeks of exercise intervention, and then resume swimming training, 1 h / day, 6 d / week, 4 weeks after the end. Body weight, weight of abdominal fat and weight of gonads (testis, epididymis, seminal vesicle) were measured 24 h after the last exercise. Serum LH, FSH and T concentrations were measured. Determination of sperm concentration and sperm motility. Results: Obesity caused a decrease in reproductive function in male mice. Moderate-load exercise and high-load exercise can significantly reduce the degree of obesity in mice, and heavy exercise to lose weight better, but only moderate exercise can significantly reverse obesity-induced gonadal coefficient of male mice, serum sex hormone levels and semen quality parameters decline. Restorative training can further restore the reproductive function of obese male mice after moderate stress exercise, but can not improve the reproductive function of obese male mice after heavy exercise. Conclusions: Both low-weight and low-weight reproductive function can be significantly reduced in moderate-load exercise and moderate-recovery exercise, but not in high-load exercise and after heavy-load exercise. Reproductive dysfunction in male mice.