背景以氨基酮戊酸(ALA)作为光敏剂的光动力疗法可以治疗多种肿瘤,然而这种治疗方法对于体积大,离体表远的实体瘤的治疗效果欠佳。本文发现,在光动力之前注射维生素D3的激活体-钙三醇后可以显著的提高其治疗效果。在小鼠的鳞状皮肤肿瘤模型中,笔者发现钙三醇通过增加粪卟啉原氧化酶和减少亚铁原卟啉合成酶的表达量使得ALA的有效成分PpⅨ在肿瘤内的积累量增加了10倍。并且经过钙三醇预处理的肿瘤在光 Background Photodynamic therapy with aminolevulinic acid (ALA) as a photosensitizer can treat a variety of tumors, however, this treatment is not effective in treating bulky, distant body solid tumors. This article found that the injection of vitamin D3 before calcitriol injection before photodynamic therapy can significantly improve its therapeutic effect. In mouse squamous skin tumor models, the authors found that calcitriol increased the accumulation of PpIX, an active ingredient of ALA, in the tumor by increasing the expression of coproporphyrinogen oxidase and reducing the expression of ferroporphyrin synthetase 10 times. And the tumor that had been pre-treated with calcitriol was in the light