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作者研究了作脾切除术的毛细胞白血病患者骨髓增生低下与脾扣押之间有无关系。了解这种关系和如何影响脾切除术的效果,就可建立预后的一些参数,预测患者缓解的程度。对65例脾切除术患者在术前和术后作血细胞计数和称脾重量。术前每例均作骨髓活检,以观察有核细胞数和毛细胞的百分比。术后1～3月评价脾切除术的效果。结果分为完全缓解(CR)、部份缓解(PR)和无效。 65例中男性54例,女性11例。年龄30～80岁。27例CR,38例PR。男女之间的生存期无统计学差异。全部65例5年生存期为68%,CR组为76%,PR组为62%。用Wilcoxon法分析这种差异无统计学意义。脾重量范围在260～4,600克,脾重量不能预言血小板和白细胞在脾切除后是否能恢复正常。骨髓活检每10
The authors investigated whether there is a relationship between low myeloproliferation and splenectomy in patients with hairy cell leukemia who underwent splenectomy. Understanding this relationship and how it affects splenectomy results in establishing some parameters of prognosis and predicting the extent of patient response. 65 cases of splenectomy patients before and after surgery for blood cell count and said spleen weight. Perioperative preoperative bone marrow biopsy to observe the number of nucleated cells and hair cells percentage. Postoperative 1 to 3 months to evaluate the effect of splenectomy. The results were divided into complete remission (CR), partial remission (PR) and invalid. Among 65 cases, 54 were male and 11 were female. Age 30 to 80 years old. 27 cases of CR, 38 cases of PR. There was no significant difference in survival between men and women. All 65 patients had a 5-year survival of 68%, a CR of 76% and a PR of 62%. Wilcoxon analysis of this difference was not statistically significant. Spleen weight range 260-4,600 grams, spleen weight can not predict whether platelets and white blood cells in spleen resection can return to normal. Bone marrow biopsy every 10