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EMS1基因(chromosom e eleven,band q13,m amm ary tumour and squamous cell carc inom a-assoc iated gene1)定位于人类染色体11q13。该基因编码产物cortactin(cortical actin-b ind ing prote in)是一种位于细胞皮质区的肌动蛋白结合蛋白,参与细胞骨架系统的调控,细胞外信号转导以及细胞黏附等过程。研究表明EMS1基因与许多肿瘤的侵袭和转移有关。
The chromosomal encephalon (EMSA) gene is located on human chromosome 11q13. The gene encoding cortactin (cortical actin-b ing ing prote in) is an actin-binding protein located in the cortex of the cell and is involved in the regulation of the cytoskeleton system, extracellular signal transduction and cell adhesion. Studies have shown that EMS1 gene is involved in the invasion and metastasis of many tumors.