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目的:探讨B型氨基端利钠肽原(NT-pro BNP)在严重创伤失血性休克患者早期目标导向治疗(EGDT)的预测价值及对预后的意义。方法:选取2014年5月至2015年5月罗定市第三人民医院ICU收治的100例严重创伤失血性休克患者,分别于入院后的第1 h、3 h、6 h、12 h、24 h,3 d测量患者的NT-pro BNP水平情况,中心静脉压、平均动脉压、SOFA评分、尿量、SCVO_2等相关指标。结果:NT-pro BNP与容量负荷之间存在相关关系。结论:从早期容量复苏始,选择多个时间点,覆盖容量复苏的全过程,动态全程监测NT-pro BNP的浓度变化,并结合多个传统观测指标,有利于对失血性休克患者的容量复苏过程进行个体化综合评估与指导。
Objective: To investigate the predictive value of early targeted therapy (EGDT) of type B NT-pro BNP in patients with severe traumatic hemorrhagic shock and its prognostic significance. Methods: One hundred patients with severe traumatic hemorrhagic shock who were admitted to the ICU of Third People’s Hospital of Luoding from May 2014 to May 2015 were enrolled in this study. The patients were admitted to hospital at 1 h, 3 h, 6 h, 12 h, 24 h The level of NT-pro BNP, central venous pressure, mean arterial pressure, SOFA score, urine output, SCVO_2 and other related indicators were measured on day 3 and day 3 respectively. Results: There was a correlation between NT-pro BNP and volume load. CONCLUSIONS: From the beginning of early volume resuscitation, multiple time points are selected to cover the whole process of volume resuscitation, and the changes of concentration of NT-pro BNP in the whole process are dynamically monitored. Combined with a number of traditional observational indexes, it is helpful for the recovery of volume in patients with hemorrhagic shock Process of individual comprehensive assessment and guidance.