论文部分内容阅读
目的分析血清缺血修饰白蛋白(IMA)对急性冠脉综合征(ACS)的诊断价值。方法检测非冠心病人群及发病12h内急性脑梗死(ACI)、不稳定心绞痛(UA)、急性心肌梗死(AMI)患者血清IMA、肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)的水平。结果 (1)UA及AMI组患者血清IMA均显著高于非冠心病组(P均<0.01),UA组cTnT及CK-MB与非冠心病组无统计学差异(P均>0.05);(2)ACI患者血清IMA值显著高于非冠心病组(P均<0.01),但均显著低于UA组及AMI组。结论 UA及AMI患者血清IMA均显著升高,因UA组心肌坏死标志物cTnT及CK-MB均无显著升高,提示IMA形成可能与心肌缺血有关,而非心肌细胞坏死所致。虽然ACI组IMA也明显高于非冠心病组,但显著低于AMI组及UA组,提示IMA的显著升高对ACS有诊断价值,但需结合其他指标综合判断。
Objective To analyze the diagnostic value of serum ischemia modified albumin (AIM) in acute coronary syndrome (ACS). Methods Serum levels of IMA, creatine kinase (CK) MB, troponin T and serum creatinine (TNF) in patients with non-coronary heart disease and patients with ACI, UA, (cTnT) levels. Results (1) Serum IMA in UA and AMI patients were significantly higher than those in non-coronary heart disease patients (all P <0.01). There was no significant difference in cTnT, CK-MB and non-coronary heart disease between UA and AMI patients (all P> 0.05) 2) The serum IMA of ACI patients was significantly higher than that of non-CHD patients (all P <0.01), but both were significantly lower than those of UA and AMI patients. Conclusions Serum IMA in patients with UA and AMI were significantly increased. There was no significant increase of cTnT and CK-MB in myocardium of UA patients, suggesting that IMA may be related to myocardial ischemia rather than necrosis of cardiomyocytes. Although the IMA of ACI group was significantly higher than that of non-coronary heart disease group, it was significantly lower than that of AMI group and UA group, suggesting that the significant increase of IMA was valuable in diagnosing ACS, but it should be combined with other indicators.