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本实验在麻醉开胸犬,采用冠状动脉左旋支恒流灌注,于搏动的和心室纤颤(VF)的心脏,研究了电刺激迷走神经(VNS)及冠状动脉内注入乙酰胆碱(ACh)对冠状动脉阻力的影响。当 VNS 和冠脉内给 ACh 时,(1)心肌内小冠状动脉阻力显著减低,而心外膜大冠状动脉阻力并无明显变化;(2)冠状动脉左旋支总阻力的减低幅度在 VF 的心脏比在搏动的心脏显著减小。以上结果表明,迷走-ACh 扩张冠脉的作用主要是舒张心肌内小冠状动脉,并可通过减低心肌收缩力而间接降低冠状动脉阻力。
In this study, anesthetized thoracotomy dogs were perfused with left anterior descending coronary artery in pulsatile and ventricular fibrillation (VF) hearts. The effects of electrical stimulation of vagus nerve (VNS) and intracoronary infusion of acetylcholine (ACh) on coronary arteries The impact of resistance. When VNS and intracoronary administration of ACh, (1) myocardial intramyocardial small coronary artery resistance decreased significantly, while there was no significant change in epicardial large coronary artery resistance; (2) coronary artery left anterior descending coronary artery resistance decreased in VF The heart is significantly reduced than in the beating heart. The above results show that the role of vagus - ACh dilation of the coronary artery is mainly the relaxation of small coronary arteries, and can indirectly reduce coronary resistance by reducing myocardial contractility.